“Clinical decisions, evidence first”
Answers NICE guideline queries in plain language with exact citations, SNOMED CT codes, and a mandatory human-review flag on every response. Built for NHS clinical settings.
Clinical Query
First-line treatment for type 2 diabetes in adults?
Evidence-Based Response
Metformin is first-line unless contraindicated (eGFR <30). Target HbA1c 48 mmol/mol for monotherapy.
Use Cases
Surface a defensible chain of evidence across millions of biomedical papers, patents, and trial registries — every claim returns with the source paragraph, DOI, and SNOMED-mapped concept so reviewers can verify in one click.
Knowledge graph · DOIOB/GYN, fertility, and paediatric queries return guideline-grounded answers overlaid with provider state, payor, and trimester context — so the same prompt yields a different, locally compliant pathway depending on member geography.
RCOG · ACOG · stateFor a patient on a long-term care pathway, the assistant retrieves the relevant NICE step, the next escalation criterion, and the eligible interventions — keeping community clinicians aligned with the latest published pathway.
NICE pathway · escalationRuns on a clinician's tablet during a home visit. Voice or typed query returns a concise NICE-grounded answer plus a one-tap audit-trail entry — designed for low-bandwidth visits where the clinician can't open a 60-page PDF.
NICE · offline-cacheQuery an internal trial-protocol corpus alongside published oncology and antiviral literature; the response cites the protocol section, the published source, and any superseding amendment so clinical-ops and regulatory teams stay synchronised.
Protocol · amendment trailA genomic variant maps to the relevant ClinVar entry, OMIM phenotype, and any NICE-recognised genomic test pathway — every output flagged with a confidence score and a mandatory clinical-scientist review before release.
ClinVar · OMIM · reviewHow It Works
Submitted through the secure NHS-authenticated interface. All queries are logged and auditable.
Embedded and matched against 50,000+ NICE guideline chunks using cosine similarity.
The top-k most relevant guideline sections are retrieved with full source metadata.
Retrieved context is passed to Gemma 4 on Azure AI with a clinically constrained system prompt.
A non-bypassable review flag is attached — the system cannot return a response without it.
The clinician receives the evidence, citations, SNOMED codes, and review flag — and decides.
System Architecture
Vector Store
Azure Cognitive Search · ada-002 embeddings · cosine similarity
Knowledge Base
NICE guidelines · BNF drug data · SNOMED CT ontology
Compliance Layer
UK GDPR Art.22 · MHRA GMLP · NHS DSP Toolkit
Sample Interaction
Clinical Query
First-line treatment for type 2 diabetes in adults?
Evidence-Based Response
Metformin is first-line unless contraindicated (eGFR <30). Target HbA1c 48 mmol/mol for monotherapy.
Guideline Citation
NICE NG28
Recommendation 1.6.1
SNOMED CT 44054006
Type 2 diabetes mellitus
Confidence
0.94
Mandatory Human Review Required
This AI-generated response must be reviewed by a qualified clinician. UK GDPR Art.22 · MHRA GMLP.